Control pairs A and B are dead, missing, or otherwise unaccounted for. Such was expected, but needless to say I'm disappointed by how quickly it happened. Not four days after testing began, they were taken. I suppose paranoia got the better of them and created a strong enough manifestation to attack them.
Meanwhile, the remaining two test pairs appear to be functioning normally. Of the four of them, however, A1's observed behaviour has become erratic, signalling possible re-infection of knowledge. The trial will continue for a further week before definitive test results can be declared. It will then take another month to see if Kainic Acid infusions are required periodically, or if a single dose is enough to be rid of It permanently. I personally hope that is not the case - my supply is extremely limited, and securing enough for the test pair was a struggle in itself.
Despite the seeming Success of The Last Resort, I still have to continue research if I have any hope of engineering less extreme remedies. On the plus side, this test has revealed just how easy it is to procure willing test subjects through incredibly easy means. in fact, I have already launched preparations for First Contact. It seems fortunate that I am so close to a mental hospital; any apparatus will be simple enough to acquire.
Progress has been made on procuring answers from M, though. Apparently walking towards a manifestation is sure to cause death, though as of yet I have no ideas how this fits in with my theory. It's a simple enough scenario to replicate ad finitum, perhaps I can observe anything unusual that may explain why It cannot harm one until they approach It.
On a less hopeful note, my own manifestations have increased in severity and frequency. The last sighting was three days ago, from a severely reduced distance. While it lasted little more than a second, it was still enough to confirm my suspicions - I am now a target, and my defences are beginning to fail.